Chapter 6. Formulation Development using Optimization
Synopsis
Author
Mrs. Gayatri Devi Medisetty
Associate Professor, Department of Pharmaceutical Technology, Viswanadha Institute of Pharmaceutical Sciences, Visakhapatnam, Andhra Pradesh
Abstract
Computer-aided formulation development employs mathematical modeling and statistical approaches to optimize pharmaceutical formulations systematically. The integration of optimization algorithms, factorial design principles, and advanced computational methods enables efficient exploration of formulation parameters and their interactions. This systematic approach reduces experimental burden, minimizes resource utilization, and accelerates the development of optimal pharmaceutical formulations. The methodology encompasses parameter selection, experimental design strategies, and statistical analysis to identify optimal formulation conditions while considering multiple quality attributes simultaneously.
Keywords: Formulation optimization; Factorial design; Design of experiments; Response surface methodology; Quality by Design (QbD)
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