Chapter 19. Drug Interactions and Adverse Effects

Author

Mrs. Krishnaveni Vydani

Associate Professor, Department of Pharmaceutics, Koringa College of Pharmacy, Korangi, Andhra Pradesh, India

Abstract

Drug interaction management requires systematic approaches to recognition, assessment, and prevention of clinically significant interactions. Recognition protocols utilize automated screening tools, clinical assessment parameters, and patient risk factor evaluation. Assessment strategies incorporate mechanistic evaluation of pharmacokinetic and pharmacodynamic interactions with severity rating scales. Prevention methods implement systematic screening procedures, alternative drug selection protocols, and monitoring strategies for unavoidable interactions. Management approaches utilize standardized interventions including dose adjustments, timing modifications, and additional monitoring requirements. Documentation systems capture interaction assessment, intervention strategies, and patient monitoring parameters through structured templates. Adverse effect recognition incorporates systematic assessment tools, causality determination methods, and severity grading scales. Reporting systems utilize standardized formats for adverse event documentation and contribute to population-level safety surveillance databases. Implementation strategies emphasize proactive screening and systematic monitoring of high-risk drug combinations

Keywords: Drug interactions, Adverse effects, Interaction screening, Safety monitoring, Event reporting

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